Response to resistive strengthening exercise training in humans with neuromuscular disease.

The role of strengthening exercise to potentially improve weakness and the functional abilities of persons with neuromuscular diseases is controversial. There are questions about the ability of diseased skeletal muscle to respond to resistance exercise, particularly in light of concerns about weakness induced by exercise. Numerous studies show promising results of strength training, although methodologic issues limit conclusions. This article reviews current knowledge in this area and provides recommendations for future investigations.